Polyplasdone crospovidone use multiple mechanisms for disintegration
Unlike other superdisintegrants, which rely principally on swelling for disintegration, Polyplasdone disintegrants use the combination of mechanisms to provide rapid disintegration. Although Polyplasdone polymers swell by 95% to 120% upon contact with water, swelling is not the only mechanism for tablet disintegration.
Polyplasdone polymers, with their porous particle morphology, will rapidly absorb water (wicking) via capillary action. During tablet compaction, the highly compressible Polyplasdone particles become highly deformed. As the deformed Polyplasdone particles come in contact with water that is wicked into the tablet, the Polyplasdone particles recover their normal structure and swell, resulting in rapid volume expansion and hydrostatic pressures that cause tablet disintegration.
Polyplasdone superdisingrants increase tablet breaking force and reduces friability
Polyplasdone polymers are significantly more compressible than other superdisintegrant allowing for tablets with higher breaking force and lower friability.
Download “Polyplasdone Superdisintegrants Product Overview”
Poor solubility + Polypladsone crospovidone = enhanced dissolution
Polyplasdone XL-10 crospovidone’s high surface area combined with unique chemistry results in high interfacial activity that serves to enhance the dissolution of poorly soluble drugs in a way that is not possible with other disintegrant technologies.
Download “Polyplasdone crospovidone: The solution for poorly soluble drugs”
Download recent article “Influence of superdisintegrants on the drug dissolution from oral
solid-dosage forms”
Nonionic superdisintegrant for improved dissolution of cationic drugs
An important formulation consideration is the potential interaction between drug actives and excipients. When working with cationic drugs, however, anionic disintegrants like croscarmellose sodium (CCS) and sodium starch glycolate (SSG) may interact with the active and
actually retard dissolution. Unlike anionic disintegrants, Polyplasdone crospovidones are nonionic and will not complex with cationic drug.
Download “Polyplasdone Crospovidone: Nonionic superdisintegrant for improved dissolution
of cationic drugs”
Download article “Effect of superdisintegrants on dissolution of cationic drugs”
Superdisintegrant for orally disintegrating and chewable tablets
Fast dissolving, fast melting, chewable and orally dissolving or disintegrating tablets are solid dosage forms that disintegrate rapidly and dissolve in the mouth without water. Polyplasdone XL-10 crospovidone is widely used in orally disintegrating tablets (ODTs) as it:
- Provides rapid disintegration
- Gives significantly higher tablet breaking force and lower friability
- Swells without gelling to provide rapid disintegration and better texture and mouthfeel
Due to its high crosslink density, Polyplasdone crospovidone swells rapidly in water without gelling. Other superdisintegrants have a lower crosslink density and, as a result, form gels when fully hydrated, particularly at the higher use levels in ODT formulations. When 1,000-mg placebo ODTs were placed in a small amount of water, the ability of Polyplasdone XL-10 crospovidone to wick water into the tablet is readily observed in the following video.
Download “Polyplasdone® Crospovidone Superdisintegrants for orally disintegrating
and chewable tablets”
Download article “Selecting superdisintegrants for orally disintegrating tablet formulations”
