Advantia coating systems
ISP offers three Advantia coating technologies for film coating of pharmaceutical and dietary supplement oral solid dosage forms.

Technology	Application	Description	Advantages
Advantia Preferred HS	Immediate Release	Based on innovative combinations of common polymer and plasticizer Pre-blended dry powder Available in white, clear and range of colors* Dispersed in water and apply	Reduced coating time-applied as high solids (up to 25%) coating suspension Improved tablet appearance Improved adhesion to difficult-to-coat tablet cores No impact on tablet dissolution
Advantia Prime	Immediate Release	Based on traditional cellulosic polymers and plasticizer combinations Pre-blended dry powder Available in white, clear and range of colors* Dispersed in water and apply	Traditional coating system with long history of use
Advantia Performance	Delayed Release (Enteric)	Based on methacrylic acid ethyl acrylate copolymer Pre-blended dry powder Available pigmented and unpigmented* Dispersed in water and apply	Simple suspension preparation – less time required One step suspension preparation

*Limited only by constraints of global color regulations for dietary supplements and pharmaceutical products.

Advantia coatings have been applied to the following types of oral solid dosage forms:

• Tablets
• Multiparticulates
• Two-piece gelatin capsules
• Soft gelatin capsules

Contact your local sales office to find the Advantia coating formulation best suited for your tablet core.

The Science of Advantia Coatings – Reduces your development time
In the development of Advantia coatings, ISP used statistical design of experiments (D.o.E) approach to evaluate the interactive effects of key film-coating ingredients. ISP uses the results of the D.o.E evaluation to create a specific data base (design space) for each type of polymer system being considered. ISP can apply the data base to create specific coating formulations for each coating application saving time consuming and costly trial and error efforts to solve coating problems.

Design space for optimizing film coating systems

To learn more, please click to view AAPS Poster, “Using D.o.E. to understand interactions between common film coating ingredients.”

To see examples of how ISP uses the responses generated from the D.o.E. to solve coating problems, please click "Predicting Coating Performance and Solving Common Film-Coating Problems Using a Formulation Database Created Using Statistical D.o.E. Predicting coating performance and solving common film-coating problems using a formulation database created using statistical D.o.E.."

Advancing the science of coatings – Advantia Preferred HS coatings
In addition to offering Advantia Prime coatings based on conventional cellulosic polymers, ISP is developing innovative coatings based on its experience as a leading polymer research company.
The ISP technical team has core strengths in design and development of novel functional systems
based on molecular structure-property relationships and a leader in polymer research.

Advantia Preferred HS coatings give you high quality coatings in record time. The product of ISP’s extensive experience as a leader in polymer research, Advantia Preferred HS coatings are specially designed to be applied at high solids concentrations. This allows the coating to be deposited faster
than a conventional coating, which improve processing time significantly. Production-scale coating
trials conducted by ISP have demonstrated that spraying Advantia Preferred HS coating suspensions
at up to 25% solids translates into a 43% savings in process time over traditional HPMC-based coating suspensions (Figure 1)

Download the Advantia Preferred HS Coating Systems Product Overview.

Technical service and support
Our coating technical service specialists are experienced in the operation of film-coating equipment ranging from lab scale to commercial production and are able to support scale-up trials or trouble-shoot current commercial production. We can assist you in selection and evaluation of a film coating formulation throughout the development process.

View article “Tablet Coating, Troubleshooting Appearance-Related Problems of Film-Coated Tablets" by Dr. Stuart Porter (April 2008)