Plasdone Povidone is a series of synthetic, water-soluble homopolymers of N-vinyl-2-pyrrolidone. ISP offers a variety of molecular weights for use as excipients in pharmaceutical applications. The different Plasdone polymers are distinguished by their K-value, a measure of specific viscosity which correlates with molecular weight.
Plasdone Polymers exhibit excellent adhesive properties, good film forming characteristics, surface active properties and high solubility in water and a number of pharmaceutically-acceptable solvents.
Plasdone K Polymers
Plasdone K polymers are suitable for most pharmaceutical applications and conform to the current monographs for Povidone.
Product Name |
K-Value |
Weight Average Molecular Weight (Mw) |
Pharmacopeial Name |
Monograph Compliance |
USP/NF |
Ph. Eur. |
JP/JPE |
Plasdone K-12 |
10.2-13.8 |
4,000 |
Povidone |
|
|
n/a* |
Plasdone K-17 |
16 -17.5 |
10,000 |
Povidone |
|
|
(JPE) |
Plasdone K-25 |
24-26 |
34,000 |
Povidone |
|
|
|
Plasdone K-29/32 |
29-32 |
58,000 |
Povidone |
|
|
|
Plasdone K-90 |
85-95 |
1,300,000 |
Povidone |
|
|
|
*Currently the JP monograph only defines Povidone grades with a nominal K-value of not less than 25 and not more than 90.The JPE monograph defines an additional Povidone grade with nominal K-value of 17.
Pyrogen-free Options: Plasdone C Polymers
Plasdone C polymers are pyrogen-free and recommended for use in applications where pyrogens may be a concern. Plasdone C-12 and C-17 polymers are typically preferred for parenteral applications, while Plasdone C-30 polymers are used in opthalmic products.
Product Name |
K-Value |
Weight Average Molecular Weight (Mw) |
Pharmacopeial Name |
Monograph Compliance |
USP/NF |
Ph. Eur. |
JP/JPE |
Plasdone C-12 |
10.2-13.8 |
4,000 |
Povidone |
|
|
n/a* |
Plasdone C-17 |
15.5 -17.5 |
10,000 |
Povidone |
|
|
(JPE) |
Plasdone C-30 |
29-32 |
58,000 |
Povidone |
|
|
|
Download Plasdone C and K Polymers Product Overview.
