Cyclodextrins are bucket-shaped oligosaccarides with a hydrophoic cavity and hydrophilic exterior. Given their molecular structure and shape, cyclodextrins function as molecular containers by entrapping guest molecules, such as active pharmaceutical ingredients (APIs), within the internal cavity.

ISP offers a range of cyclodextrins manufactured by Wacker Chemie for pharmacuetical applications.  Our alliance with Wacker combines Wacker’s manufacturing expertise and our pharmecuetical technical sales and service to provide solutions to pharmaceutical formulations.

	Product Name	Cyclodextrin Type	Aqueous Solubility (g/100ml water @ 25°C)	Compendial Name	Monograph Compliance
					USP/NF	Ph. Eur	Japan
Native	CAVAMAX W6 Pharma	Alpha	13	Alfadex			(JPE)
	CAVAMAX W7 Pharma	Beta	1.7	Betadex			(JPE)
	CAVAMAX W8 Pharma	Gamma	23	Gamma Cyclodextrin		In process	n/a
Derivatives	CAVASOL W7 HP Pharma	Hydroxy propyl- beta	158	Hydroxypropyl betadex			n/a
	CAVITRON W7 HP5 Pharma	Hydroxy propyl- beta	158	Hydroxypropyl betadex			n/a
	CAVITRON W7 HP7 Pharma	Hydroxy propyl- beta	239	Hydroxypropyl betadex			n/a

n/a= not applicable

The CAVITRON grades of hydroxypropyl- β-Cyclodextrin are manufactured to minimize endotoxin levels and are considered acceptable for use in parenteral applications.  The CAVITRON grades of hydroxypropyl- β-Cyclodextrin differ by degree of substitution or average number of hydroxypropyl groups per each cyclodextrin molecule:

Download CAVAMAX, CAVITRON and CAVASOL Product Overview.

CAVAMAX® and CAVASOL® are registered trademarks of Wacker Chemie AG.

Benefits and applications

• Enhances bioavailability by increasing water solubility of poorly-soluble drug actives
  
  
• Improves the light, thermal and oxidative stability of drug actives through formation of inclusion complexes
  
  
• Reduces dermal, gastrointestinal or ocular irritation through complex formation
  
  
• Masks unpleasant tastes and odors of drug actives to improve patient compliance
  
  
• Prevents dug-drug and drug additive interactions
  
  
• Simplifies product handling by reducing volatility of actives or converting liquids to powders.